Grounded in Neither Superstition nor Prejudice with Full Respect for Equal Protection
by John Otrompke
As I describe in my recent Lancet article, when the Endocrine Society issued its updated clinical practice guideline on sex change (“gender affirmation”) procedures late last fall, the authors acknowledged a trend that was already underway.
The guideline described four kinds of sex change procedures in children: social transitioning, the administration of puberty-blocking hormones, gender affirmation hormones, and surgery.
Regarding social transitioning, I believe a child should be free to tell anyone they are whatever they want to be, to transition again, and to transition back, any time they want to. That’s a child’s inherent imaginative freedom, and obviously such a procedure is non-invasive and reversible. Unlike the authors of the guideline, I don’t even think consultation with a psychologist is important if a child undertakes social transitioning.
Puberty-blocking hormones administered in children as young as 9 years old prevent the child from undergoing puberty, while sex change hormones cause the child to develop sex characteristics of the other gender.
But for bioethical reasons that have nothing to do with superstition, I hope, I am opposed to most of these medical procedures in children. I don’t believe I have a fundamental difference from many of my colleagues; I suspect the appearance of the seeming difference of opinion arises because many of my colleagues conflate the equal protection issue with the bioethical issue. I entirely support the equal protection of transgendered people, as well as LGBTQIA+ freedom and equality.
But from a bioethics perspective, I don’t think these medical procedures should be performed in minors.
The Procedures Expose Children to Medical Risks
Here is why I take that view. Under current principles, a minor cannot consent to a medical procedure that presents some risk of harm. Nor can a parent give effective informed consent on behalf of a child to risky medical procedure which cannot benefit the child. For example, court cases that held that a child’s parents cannot consent to a child’s participation in risky non-therapeutic research, such as an experiment that may some day benefit patients with a disease the child does not have.
‘Gender affirmation’ procedures present certain risks. For example, any surgery presents certain non-negligible hazards, such as death under anesthesia. Other things can go wrong, such as stenosis of the vagina, or a failure of the neogenital nerve graft, leaving the patient without any feeling in their sex organs. The fact that these events may be rare doesn’t mean they aren’t serious. And what about other fatal adverse events during the procedure?
Even the administration of hormone blockers, which advocates claim is reversible, comes with certain risks, because the delay of puberty is associated with weaker bones.
In addition, some studies have found that trans-women experience an increased risk for major adverse coronary events such as ischemic stroke and pulmonary embolism.
What about regrets? The physicians who have performed the vast majority of sex change operations in Europe recently published very extensive data analyzing their large and longstanding cohort of almost 7,000 patients since 1972 for a variety of adverse events, including regret. The researchers found that a very small percentage (less than 1%) of patients reported regretting their sex change procedures, but they only looked at patients who underwent surgery (not those who just underwent hormone treatment). In my opinion, those findings were also flawed by the large proportion (36%) of patients who were lost to follow-up, and could not or would not report on whether they experienced any regret.
Most Children Desist Following Puberty
Given the risks that are attendant upon sex change procedures, do children enjoy any benefit from the procedures, such as puberty-blocking and sex change hormone treatment, or surgery, that a parent or guardian could weigh in deciding whether the risks are justified?
They do, according to advocates for gender affirmation medical treatment in children (such as Dr. Steve Rosenthal, MD, an author on the guideline), who say that children who undergo puberty in their “birth-assigned gender” have a substantially higher risk of suicide and anxiety, for example. (One study, however, which examined data from nearly 1,000 transwomen found that an increased risk of suicide was largely responsible for a risk of death that was roughly 1.5 times as great as that in the general population).
The other problem with this analysis is that the “gender dysphoria” (unhappiness with one’s birth-assigned gender) desists in 60 to 85% of children with the condition once they go through puberty.
Advocates, and the authors of the guideline, argue that the high remission rate is due to the use of inaccurate methods of diagnosis. “Intense” anatomic dysphoria and “Real Life Experience” are the key to identifying those children whose dysphoria will persist into adulthood, according to some researchers.
In my opinion, this points out the flawed nature of contemporary psychology, which I regard as a non-mature science of inherently subjective, intangible matters. Did health care providers use flawed methods to diagnose this condition in the past? How many children received the procedures based on false positives? Are the doctors really certain they have the diagnostic criteria right this time?
If the medical procedures are associated with certain non-negligible risks, and many children would enjoy no benefit from the procedure because the condition giving rise to the need for the procedure would resolve on its own if the child were to go undergo puberty without medical treatment, it seems to me that the procedures are experimental, and because they it is questionable whether they offer any medical benefit, it is unnecessary to undergo the invasive procedures in most children.
Hence, I conclude that the administration of physical sex change procedures, including puberty-blocking hormones, is unethical in children.
Thoughtful opinions to the contrary are welcome. If you disagree with me, you may write to me telling me why; if I like your commentary, I may publish it on my website.